Department of Pathology
Brigham and Women's Hospital
A teaching Affliate of Harvard Medical School
 

Name and Present Position:

RICHARD N. MITCHELL, Pathologist

Address:

Brigham and Women's Hospital, Department of Pathology, 75 Francis Street, Boston, MA

Medical School (including school name, date and degree awarded):

1984 MD, Harvard Medical School, Boston, MA
  Graduate Medical Education (including dates and institution of internships, residencies, fellowships, etc.):

1980 PhD, Rockefeller University, New York, NY
1984-85 Medical Internship, Beth Israel Hospital, Boston, MA
1985-87 Resident in Pathology, Brigham and Women's Hospital
1987-88 Chief Resident in Pathology, Brigham and Women's Hospital
1988-90 Post-doctoral Research Fellow, Brigham and Women's Hospital

Certification:

1988 American Board of Pathology (Anatomic)

Current Academic Appointment:

Associate Professor of Pathology, Harvard Medical School

Current Medical Staff Appointments:

Pathologist, Brigham and Women's Hospital

Honors and Awards:

1995 Irving M. London Teaching Award
2000 Faculty Prize for Excellence in Teaching, Harvard Medical School
2003 Health Sciences and Technology Teaching Award
2004 Thomas A. McMahon Mentoring Award
2005 Harvard Medical School Humanism in Medicine Award

Selected Bibliography:

  • Barnes KA, Mitchell RN. Detection of functional class II-associated antigen: Role of a low density endosomal compartment in antigen processing. J Exp Med 1995; 181:1715-1727.
  • Mitchell RN, Barnes KA, Grupp SA, Sanchez M, Misulovin Z, Nussenzweig MC, Abbas AK. Intracellular targeting of antigens internalized by membrane immunoglobulin in B lymphocytes. J Exp Med 1995; 181:1705-1714.
  • Nagano H, Mitchell RN, Taylor MK, Hasegawa S, Libby P. Interferon-gamma deficiency prevents coronary arteriosclerosis but not myocardial rejection in transplanted mouse hearts. J Clin Invest 1997; 100:550-557.
  • Mitchell RN, Jonas RA, Schoen FJ. Pathology of explanted cryopreserved allograft human valves: Comparison with aortic valves from orthotopic heart transplants. J Thorac Cardiovasc Surg 1998; 115:118-127.
  • Nagano H, Libby P, Taylor MK, Hasegawa S, Stinn JL, Tilney NL, Mitchell RN. Coronary arteriosclerosis following T cell-mediated injury in murine cardiac allografts: Role of interferon-gamma. Am J Pathol 1998; 152:1187-1197.
  • Furukawa Y, Becker G, Stinn JL, Shimizu K, Libby P, Mitchell RN. IL-10 augments allograft arterial disease: Paradoxical effects of IL-10 in vivo. Am J Pathol 1999; 155:1929-1940.
  • Shimizu K, Schonbeck U, Mach F, Libby P, Mitchell RN. Host CD40 ligand deficiency induces long-term allograft survival and donor-specific tolerance in mouse cardiac transplants, but does not prevent graft arteriosclerosis. J Immunol 2000; 165:3506-3518.
  • Shimizu K, Sugiyama S, Aikawa M, Fukumoto Y, Rabkin E, Libby P, Mitchell RN. Host bone marrow cells are a source of donor intimal smooth muscle-like cells in murine aortic transplant arteriopathy. Nature Med 2001; 7:738-741.
  • Furukawa Y, Libby P, Stinn JL, Becker G, Mitchell RN. Cold ischemia induces isograft arteriopathy, but does not augment allograft arteriopathy arteriopathy in non-immunosuppressed hosts. Am. J. Pathol. 2002;160:1077-1087.
  • Shimizu K, Aikawa M, Takayama K, Libby P, Mitchell RN. Direct anti-inflammatory mechanisms contribute to attenuation of experimental allograft arteriosclerosis by statins. Circulation 2003; 108:2113-2120
  • Shimizu K, Shichiri M, Libby P, Lee RT, Mitchell RN. Th2-predominant inflammation and blockade of IFN-gamma signaling induce aneurysms in allografted aortas. J Clin Invest. 2004;114:300-8