Dr. Silberstein

	Department of Pathology
	Brigham and Women's Hospital
	A teaching Affliate of Harvard Medical School
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Name and Present Position:

LESLIE E. SILBERSTEIN, Director, Joint Program in Transfusion Medicine

Address:

Karp Family Research Building, One Blackfan Circle, Room 10217, Boston, Massachusetts 02115

Medical School (including school name, date and degree awarded):

1977 MD, University of Leiden, The Netherlands

Graduate Medical Education (including dates and institution of internships, residencies, fellowships, etc.):

1977-1978 Intern in Internal Medicine, Georgetown University Medical Division, Washington, DC
1978-1980 Resident in Internal Medicine, St. Francis Hospital and Meidcal Center, Hartford, CT
1980-1981 Clinical Fellowship in Hematology/Oncology, Dept of Medicine, Tufts-New Eng. Med. Ctr., Boston, MA
1981-1983 Fellowship in Blood Bank, Tufts-New England Medical Center

Certification:

1980 American Board of Internal Medicine
1982 American Board of Internal Medicine (Hematology)
1983 American Board of Pathology (Blood Banking)

Current Academic Appointment:

Professor of Pathology, Harvard Medical School, Boston, MA

Current Medical Staff Appointment:

Director, Joint Program in Transfusion Medicine/Blood Bank, Brigham and Women's Hospital, Children's Hospital, and Dana Farber Cancer Institute, Boston, MA

Selected Bibliography:

Rao SP, Riggs JM, Friedman DF, Scully M, LeBien TW, Silberstein LE. Biased VH gene usage in early lineage human B cells: Evidence for preferential rearrangement in the absence of selection. J Immunol 1999; 163:2732-2740.
Honczarenko M, Douglas RS, Mathias C, Lee B, Ratajczak MZ, Silberstein LE. SDF-1 responsiveness does not correlate with CXCR4 expression levels of developing human bone marrow B cells. Blood 1999; 94:2990-2998.
Malka M, Rozmyslowicz T, Lee B, Murphy SL, Pietrzkowski Z, Gaulton GN, Silberstein LE, Ratajczak MZ. Bone marrow CD34+ cells and megakaryoblasts secrete B-chemokines that block infection of hematopoietic cells by M-tropic R5 HIV. J Clin Invest 1999; 104:1739-1749.
Cunto G, Honczarenko M, Przybilski G, Monroe J, Silberstein LE. Evidence that immunoglobulin specificities of AIDS-related lymphoma are not directed to HIV-related antigens. Blood 2000; 95:1393-1399.
Silberstein LE, Toy P. Research opportunities in transfusion medicine. J Am Med Assoc 2001; 285(5):577-580.
Marek Honczarenko, Yi Le, Aleksandra M. Glodek, Marcin Majka, James J. Campbell, Mariusz Z. Ratajczak, and Leslie E. Silberstein. CCR5-binding chemokines modulate CXCL12 (SDF-1)-induced responses of progenitor B cells in human bone marrow through heterologous desensitization of the CXCR4 chemokine receptor. Blood 2002 100:2321-2329.
Glodek, Aleksandra M., Honczarenko, M., Le,Y., Campbell, J.J., Silberstein, L.E., Sustained Activation of Cell Adhesion is a Differentially Regulated Process in B Lymphopoiesis. Journal of Experimental Medicine, 197:4, 1-14, 2003.
Burger, M., Glodek, A., Hartmann, T., Schmitt-Graff, A., Silberstein, L.E., Fujii, N., Kipps, T., Burger, J. Functional Expression of CXCR4 (CD184) on Small-Cell Lung Cancer Cells Mediates Migration, Integrin Activation, and Adhesion to Stromal Cells. Oncogene, 22, 8093-8101, 2003.
Silberstein, L.E., Cunningham, M.J. Autoimmune Hemolytic Anemias, In: Blood Banking and Transfusion Medicine, Basic Principles & Practice, eds Hillyer, C.D., Silberstein, L.E., Ness, P.M., Anderson, K.C., Churchill Livingstone, 2003.
Benjamin, R.J., Friedman, D.F., Silberstein, L.E., Sloan, S.R., Webb, I. Transfusion Medicine, In: Nathan and Oski’s Hematology of Infancy and Childhood, eds Nathan, D.G., Orkin, S.H., Look, A.T., Ginsberg, D., W.B. Saunders, Philadelphia, PA. 2003.
Sloan, S.R. and Silberstein, L. E. Transfusion Medicine. In: Clinical Hematology and Oncology, Presentation, Diagnosis, and Treatment, eds. Furie, B., Cassileth, P. A., Atkins, M. B., Mayer, R. J., Churchill Livingstone, 2003.
Campbell, J., Sloan, S., Silberstein, L. E., “Leukocyte Trafficking,” In: Hematology: Basic Principles and Practice, 4th Edition. Eds. Hoffman et al. 2005.
Le, Y., Honczarenko, M., Glodek, A.M., Ho, D., Silberstein, L.E. CXC Chemokine Ligand 12-Induced Focal Adhesion Kinase Activation and Segregation into Membrane Domain is Modulated by Regulator of G Protein Signaling 1 in Pro-B Cells. Journal of Immunology, 2582-2590, 2005.
Mazo, I.B., Honczarenko, M., Leung, H., Cavanagh, L.L., Bonasio, R., Weninger, W., Engelke, K., Xia, L., McEver, R.P., Koni, P.A., Silberstein, L.E., von Andrian, U.H. Bone Marrow Is a Major Reservoir and Site of Recruitment for Central Memory CD8+ T Cells. Immunity, 22(2):259-270, 2005.
Honczarenko, M., Lu, B., Nicholson-Weller, A., Gerard, N.P., Silberstein, L.E., Gerard, C. C5L2 receptor is not involved in C3a/C3a-desArg-mediated enhancement of bone marrow hematopoietic cell migration to CXCL12. Leukemia. Doi: 10.1038/sj.leu.2403862. [Epub ahead of print]. 2005.
Honczarenko, M., Ratajczak, M.Z., Nicholson-Weller, A., Silberstein, L.E. Complement C3a Enhances CXCL12 (SDF-1)-Mediated Chemotaxis of Bone Marrow Hematopoietic Cells Independently of C3a Receptor (C3aR). J. Immunology. 2005. In Press.