Dr. Jonathan Fletcher

	Department of Pathology
	Brigham and Women's Hospital
	A teaching Affliate of Harvard Medical School
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Name and Present Position:

JONATHAN A. FLETCHER, Cytogeneticist

Address:

Brigham and Women's Hospital, Department of Pathology, 75 Francis Street, Boston, MA

Medical School (including school name, date and degree awarded):

1981 MD, Boston University, Boston, MA

Graduate Medical Education (including dates and institution of internships, residencies, fellowships, etc.):

1981-1982 Intern in Medicine, University Hospital, Boston, MA
1982-1984 Resident in Medicine, University Hospital
1984-1985 Chief Resident in Medicine, University Hospital
1986-1989 Clinical and Research Fellow, Ped. Oncol., Dana-Farber Cancer Inst. and Chil-dren's Hosp., Boston, MA
1988-1989 Research Fellow in Pathology, Brigham and Women's Hospital

Certification:

1985 American Board of Medicine (Internal Medicine)
1990 American Board of Genetics (Cytogenetics)
1995 American Board of Medicine (Oncology)

Current Academic Appointment(s):

Associate Professor of Pathology and Pediatrics, Harvard Medical School, Boston, MA
Member, Division on Aging, Harvard Medical School

Current Medical Staff Appointment(s):

Cytogeneticist, Brigham and Women's Hospital
Associate in Medicine and Pathology, Children's Hospital
Staff Medical and Pediatric Oncologist, Dana-Farber Cancer Institute
Clinical Associate in Pathology, Massachusetts General Hospital, Boston, MA

Selected Bibliography:

Xiao S, McCarthy J, Aster JC, Fletcher JA. ZNF198-FGFR1 transforming ability depends on a novel proline-rich ZNF198 oligomerization domain. Blood 2000; 96:699-704.
Kroll TG, Pecciarini L, Chen C-J, Mueller E, Sarraf P, Spiegelman BM, Fletcher JA. PAX8-PPARgamma1 fusion in human thyroid carcinoma. Science 2000; 289:1357-1360.
French CA, Miyoshi I, Kubonishi I, Kroll TG, Dal Cin P, Vargas SO, Perez-Atayde A, Fletcher JA. BRD4 bromodomain gene rearrangement in aggressive carcinoma with translocation t(15;19). Am J Pathol 2001; 159:1987-1992.
Rubin BP, Singer S, Tsao C, Duensing A, Lux ML, Ruiz R, Hibbard MK, Chen CJ, Xiao S, Tuveson DA, Demetri GD, Fletcher CD, Fletcher JA. KIT activation is a ubiquitous feature of gastrointestinal stromal tumors. Cancer Res 2001; 61:8118-8121.
French CA, Miyoshi I, Kubonishi I, Grier HE, Perez-Atayde A, Fletcher JA. BRD4-NUT fusion oncogene: A novel mechanism in aggressive carcinoma. Cancer Res 2003; 63:304-307.
Davis IJ, Hsi BL, Arroyo JD, Vargas SO, Yeh YA, Motyckova G, Valencia P, Perez-Atayde AR, Argani P, Ladanyi M, Fletcher JA, Fisher DE. Cloning of an Alpha-TFEB fusion in renal tumors harboring the t(6;11)(p21;q13) chromosome translocation. Proc Natl Acad Sci U S A 2003;100:6051-60656.
Heinrich MC, Corless C, Duensing A, McGreevey L, Chen C-J, Joseph N, Singer S, Griffith DJ, Haley A, Town A, Demetri GD, Fletcher CDM, Fletcher JA. PDGFRA activating mutations in gastrointestinal stromal tumors. Science 2003; 299:708-710.