1996 Ph.D. (Medical Sciences) University of Alberta, Canada
1996-1998 NSERC Research Fellow (Molecular Cytogenetics), Department of Pathology, Cambridge University, England
1999-2001 Clinical Fellow Cytogenetics, American Board of Medical Genetics Training Program, Harvard Medical School, Boston, MA

Certification (list all):

2002 American Board of Medical Genetics (Clinical Cytogenetics)

Current Academic Appointment:

Director, Dana Farber / Harvard Cancer Center Cytogenetics Core
Assistant Professor in Pathology, Harvard Medical School
Associate Faculty Member, MIT Broad Institute

Current Medical Staff Appointment(s):

Associate Cytogeneticist, Brigham and Women's Hospital

Selected Bibliography:

• Lee C, Murray MF, Miron PM, Marsden D, Irons M, Wilkins-Haug LE, Morton CC. Clinical picture: Multicolor karyotyping. Lancet 2001; 357: 1240.
• Zhu C, Mills KD, Ferguson DO, Lee C, et al. Unrepaired DNA breaks in p53-deficient cells lead to oncogenic gene amplification subsequent to translocations. Cell 2002; 109:811-821.
• Paw BH, Davidson AJ, Zhou Y, Li R, Pratt SJ, Lee C, et al. Cell-specific mitotic defect and dyserythropoiesis associated with erythroid band 3 deficiency. Nat Genet 2003; 34: 59-64.
• Bassing CH, Suh H, Ferguson DO, Chua KF, Manis J, Eckersdorff M, Gleason M, Bronson R, Lee C, Alt FW. Histone H2AX: A dosage dependent suppressor of oncogenic translocations and tumors. Cell 2003; 114: 359-370.
• Iafrate AJ, Feuk L, Rivera MN, Listewnik ML, Donahoe PK, Qi Y, Scherer SW, Lee C. Detection of large-scale variation in the human genome. Nat Genet 2004; 36: 949-51.
• Garraway LA, et. al. Integrative genomic analysis identify MITF as a lineage survival oncogene amplified in malignant melanoma. Nature 2005; 436: 117-122.
• McCarroll SA, et. al. Common deletion variants in the human genome. Nat Genet 2006; 38: 86-92.
• Perry GH, Tchinda J, McGrath SD, Zhang J, Picker SR, Caceres AM, Iafrate AJ, Tyler-Smith C, Scherer SW, Eichler EE, Stone AC, Lee C. Hotspots for copy number variation in chimpanzees and humans. Proc Natl Acad Sci USA 2006; 103: 8006-8011.
• Redon R, et. al. Global variation in copy number in the human genome. Nature 2006; 444: 444-454.
• Khaja R, et al. Genome assembly comparison to identify structural variants in the human genome. Nat Genet 2006; 38: 1413-18.
• Stranger BE, et al. Relative impact of nucleotide and copy number variation on gene expression phenotypes. Science 2007; 315: 848-853.
  
• Engelman, et al. MET amplification leads to gefitinib resistance via ERBB3 in EGFR mutant lung cancer. Science 2007; 316: 1039-1043.
  
• Freeman. Definition of the zebrafish genome using flow cytometry and cytogenetic mapping. BMC Genomics 2007; 8: 195.
  

Reviews:

• Lee C. Vive la difference! Nat Genet 2005; 37: 660-1
• Nadeau J, Lee C. Copies count. Nature 2006; 439: 798-9.
• Freeman JL, Perry GH, Feuk L, Redon R, McCarroll SA, Altshuler DM, Aburtani H, Jones K, Tyler-Smith C, Hurles ME, Carter NP, Scherer SW, Lee C. Copy number variation: New insights into genome diversity. Genome Res 2006; 16: 949-61.
• Tchinda J, Lee C. Using microarray-based comparative genomic hybridization to detect copy number variation. Biotechniques 2006; 41: 385-90.
• Eichler EE, et al. Completing the map of human human genetic variation. Nature 2007; 447: 161-165.
  
• Scherer SW, et al. Challenges and standards in integrating surveys of structural variation. Nat Genet 2007; 39: S7-S15.
  
• Lee C, et al. Copy number variations and clinical cytogenetic diagnosis of constitutional disorders. Nat Genet 2007; 39: S48-S54.